Simulation-based reconstruction of absolute activities from the (99m)Tc/(111)In dual-isotope SPECT/CT: phantom experiments and imaging of neuroendocrine tumors.
Identifieur interne : 000401 ( Main/Exploration ); précédent : 000400; suivant : 000402Simulation-based reconstruction of absolute activities from the (99m)Tc/(111)In dual-isotope SPECT/CT: phantom experiments and imaging of neuroendocrine tumors.
Auteurs : RBID : pubmed:23615334English descriptors
- KwdEn :
- MESH :
- chemical , diagnostic use : Indium Radioisotopes, Technetium.
- instrumentation : Multimodal Imaging.
- methods : Image Processing, Computer-Assisted.
- radionuclide imaging : Neuroendocrine Tumors.
- Humans, Phantoms, Imaging, Positron-Emission Tomography, Tomography, X-Ray Computed.
Abstract
We investigate the quantitative accuracy of the reconstruction of absolute (99m)Tc and (111)In activities from (99m)Tc/(111)In dual-isotope SPECT studies. The separate reconstruction of two images is achieved by applying Monte Carlo simulation-based corrections for self-scatter and cross-talk between energy windows. For method evaluation, a series of (99m)Tc/(111)In physical phantom experiments was performed using a clinical SPECT/CT camera. The containers were filled with different ratios of (99m)Tc and (111)In activities to create cross-talk with varying severity levels. In addition, we illustrate the performance of our method by reconstructing images from four simultaneous (99m)Tc/(111)In SPECT/CT studies of neuroendocrine patients. Similarly to the phantom experiments, clinical cases provide examples with different severity of cross-talk. Phantom experiments showed that Monte Carlo simulation-based corrections improved both quantitative accuracy and visual properties of (99m)Tc and (111)In images. While the errors of absolute activities for both tracers in six containers ranged from 16% to 75% if no corrections for self-scatter and cross-talk were applied, these errors decreased to below 10% when images were reconstructed with the aforementioned corrections. These activities were measured using regions of interest larger than the true sizes of the containers in order to account for the spill-out effect. Analysis of patient studies confirmed that accurate simulation-based compensations improved resolution and contrast for both (99m)Tc and (111)In images.
DOI: 10.1088/0031-9155/58/10/3339
PubMed: 23615334
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Simulation-based reconstruction of absolute activities from the (99m)Tc/(111)In dual-isotope SPECT/CT: phantom experiments and imaging of neuroendocrine tumors.</title><author><name sortKey="Shcherbinin, S" uniqKey="Shcherbinin S">S Shcherbinin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Radiology, University of British Columbia, 366-828 West 10th Avenue, Vancouver BC, V5Z 1M9, Canada. shcher2@mail.ubc.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Radiology, University of British Columbia, 366-828 West 10th Avenue, Vancouver BC, V5Z 1M9</wicri:regionArea></affiliation></author><author><name sortKey="Chamoiseau, S" uniqKey="Chamoiseau S">S Chamoiseau</name></author><author><name sortKey="Celler, A" uniqKey="Celler A">A Celler</name></author></titleStmt><publicationStmt><date when="2013">2013</date><idno type="doi">10.1088/0031-9155/58/10/3339</idno><idno type="RBID">pubmed:23615334</idno><idno type="pmid">23615334</idno><idno type="wicri:Area/Main/Corpus">000662</idno><idno type="wicri:Area/Main/Curation">000662</idno><idno type="wicri:Area/Main/Exploration">000401</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Humans</term><term>Image Processing, Computer-Assisted (methods)</term><term>Indium Radioisotopes (diagnostic use)</term><term>Multimodal Imaging (instrumentation)</term><term>Neuroendocrine Tumors (radionuclide imaging)</term><term>Phantoms, Imaging</term><term>Positron-Emission Tomography</term><term>Technetium (diagnostic use)</term><term>Tomography, X-Ray Computed</term></keywords><keywords scheme="MESH" type="chemical" qualifier="diagnostic use" xml:lang="en"><term>Indium Radioisotopes</term><term>Technetium</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Multimodal Imaging</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Image Processing, Computer-Assisted</term></keywords><keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Neuroendocrine Tumors</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Phantoms, Imaging</term><term>Positron-Emission Tomography</term><term>Tomography, X-Ray Computed</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We investigate the quantitative accuracy of the reconstruction of absolute (99m)Tc and (111)In activities from (99m)Tc/(111)In dual-isotope SPECT studies. The separate reconstruction of two images is achieved by applying Monte Carlo simulation-based corrections for self-scatter and cross-talk between energy windows. For method evaluation, a series of (99m)Tc/(111)In physical phantom experiments was performed using a clinical SPECT/CT camera. The containers were filled with different ratios of (99m)Tc and (111)In activities to create cross-talk with varying severity levels. In addition, we illustrate the performance of our method by reconstructing images from four simultaneous (99m)Tc/(111)In SPECT/CT studies of neuroendocrine patients. Similarly to the phantom experiments, clinical cases provide examples with different severity of cross-talk. Phantom experiments showed that Monte Carlo simulation-based corrections improved both quantitative accuracy and visual properties of (99m)Tc and (111)In images. While the errors of absolute activities for both tracers in six containers ranged from 16% to 75% if no corrections for self-scatter and cross-talk were applied, these errors decreased to below 10% when images were reconstructed with the aforementioned corrections. These activities were measured using regions of interest larger than the true sizes of the containers in order to account for the spill-out effect. Analysis of patient studies confirmed that accurate simulation-based compensations improved resolution and contrast for both (99m)Tc and (111)In images.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">23615334</PMID><DateCreated><Year>2013</Year><Month>04</Month><Day>30</Day></DateCreated><DateCompleted><Year>2013</Year><Month>11</Month><Day>14</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1361-6560</ISSN><JournalIssue CitedMedium="Internet"><Volume>58</Volume><Issue>10</Issue><PubDate><Year>2013</Year><Month>May</Month><Day>21</Day></PubDate></JournalIssue><Title>Physics in medicine and biology</Title><ISOAbbreviation>Phys Med Biol</ISOAbbreviation></Journal><ArticleTitle>Simulation-based reconstruction of absolute activities from the (99m)Tc/(111)In dual-isotope SPECT/CT: phantom experiments and imaging of neuroendocrine tumors.</ArticleTitle><Pagination><MedlinePgn>3339-57</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1088/0031-9155/58/10/3339</ELocationID><Abstract><AbstractText>We investigate the quantitative accuracy of the reconstruction of absolute (99m)Tc and (111)In activities from (99m)Tc/(111)In dual-isotope SPECT studies. The separate reconstruction of two images is achieved by applying Monte Carlo simulation-based corrections for self-scatter and cross-talk between energy windows. For method evaluation, a series of (99m)Tc/(111)In physical phantom experiments was performed using a clinical SPECT/CT camera. The containers were filled with different ratios of (99m)Tc and (111)In activities to create cross-talk with varying severity levels. In addition, we illustrate the performance of our method by reconstructing images from four simultaneous (99m)Tc/(111)In SPECT/CT studies of neuroendocrine patients. Similarly to the phantom experiments, clinical cases provide examples with different severity of cross-talk. Phantom experiments showed that Monte Carlo simulation-based corrections improved both quantitative accuracy and visual properties of (99m)Tc and (111)In images. While the errors of absolute activities for both tracers in six containers ranged from 16% to 75% if no corrections for self-scatter and cross-talk were applied, these errors decreased to below 10% when images were reconstructed with the aforementioned corrections. These activities were measured using regions of interest larger than the true sizes of the containers in order to account for the spill-out effect. Analysis of patient studies confirmed that accurate simulation-based compensations improved resolution and contrast for both (99m)Tc and (111)In images.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Shcherbinin</LastName><ForeName>S</ForeName><Initials>S</Initials><Affiliation>Department of Radiology, University of British Columbia, 366-828 West 10th Avenue, Vancouver BC, V5Z 1M9, Canada. shcher2@mail.ubc.ca</Affiliation></Author><Author ValidYN="Y"><LastName>Chamoiseau</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Celler</LastName><ForeName>A</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>04</Month><Day>25</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Phys Med Biol</MedlineTA><NlmUniqueID>0401220</NlmUniqueID><ISSNLinking>0031-9155</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>7440-26-8</RegistryNumber><NameOfSubstance>Technetium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Image Processing, Computer-Assisted</DescriptorName><QualifierName MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="Y">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Multimodal Imaging</DescriptorName><QualifierName MajorTopicYN="Y">instrumentation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Neuroendocrine Tumors</DescriptorName><QualifierName MajorTopicYN="Y">radionuclide imaging</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Phantoms, Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Positron-Emission Tomography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Technetium</DescriptorName><QualifierName MajorTopicYN="Y">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Tomography, X-Ray Computed</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2013</Year><Month>4</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>4</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>4</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>11</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1088/0031-9155/58/10/3339</ArticleId><ArticleId IdType="pubmed">23615334</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=IndiumV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000401 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000401 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= *** parameter Area/wikiCode missing ***
|area= IndiumV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:23615334
|texte= Simulation-based reconstruction of absolute activities from the (99m)Tc/(111)In dual-isotope SPECT/CT: phantom experiments and imaging of neuroendocrine tumors.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:23615334" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a IndiumV2
| This area was generated with Dilib version V0.5.76. |  |